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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c580a6d4de27771fa79011ffde2bc29be43a44f9f7265d25144d8cbd6636f7c9' 
  AND token = 'tzade1KwWI8gMTpsDUWnJ+aXsjzBNn9Uj966UyntuOs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}