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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '750ce828d554096dd29eb045bd6b147b825451b37d1f22b3c18d1fe15cc162bc' 
  AND token = 'uCbIxGXu+/qxVTNtOxR6jpT0O+x9r9pG+IbnFsg/eNw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}