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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a218d9ee067d580188c52127a6b65c2b16910dda2d9ed3987af2a30bb216854f' 
  AND token = 'DyDE8sSk3K5jreRZVn62oGYrtQvKFx1jng3k/RCI52U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}