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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5189e1af1ce354f5f0e40f981a5d280821acaf2cdefbdd19d522fd20094dd233' 
  AND token = '46ePTUpKmAqI4l91DTzmbyMe8Yr9Ypo/fLT7ODSh3mc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}