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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f6d480d8e54dbfb4f00c9f7bd77a6fddf01b06af377054c994279a4e153ad382' 
  AND token = 'EO2At9dKCqGtqshe1q5uJNdnleVCw0uuPf4qog5ujsg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00072

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}