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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e99a21e47fa930aba6dba92b3ed2e3afe72cb6a53381011f08546ed9a1d7b022' 
  AND token = 'j6Ad35TlYDg+BUSQeJWkIaT7GqFaeDDJXqhbZh+XO7Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}