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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72d8ea694e13c0b87a3c3bebbe7e01c5631096c4eca6269efbc0e367302a3255' 
  AND token = 'nmJNTHFxqcYB/ZtlBquNSTcKUi3ti+ImhO5eFkxFqls=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}