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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'afe4646bbc97365a6436a01546818ecfd36b645a26ca3662b677bc541facf623' 
  AND token = 'x+MIfOBn91Um2RmxnzwpJzblxo1G/vuma3+sARJ3yN4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}