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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4b7fde76355649e8777fc5e1105021846b0affeaef1c218e64f8a6067bc6327' 
  AND token = '2n70oXT7Re+DeZPniNFa4ygvH0eu5oVb5VXSWkb8PI4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}