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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f0759eb60f01e7bee4f6fd4aeed7808007d07f32d3ff07484321ed6a837f34b6' 
  AND token = 'rU07PJ8UtNd/DNWcc7HFz1M13GKYT3wbTDHvVQAWfKA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}