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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '427b4dd0625f358fec80930f553e5f4922565e4c563faa1a21d39b6d32bdcc0f' 
  AND token = 'tjU8Wprsrwt7iA3dFoPdXC9+Yzkcaww4zoEl/9VjIQI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}