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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb16c2b6f5b5d3856774c01f78138ad0196090063daef207c05f64b629c32375' 
  AND token = 'rSZ5KUZiWLCjIvdC4+6qAH39qplPuFZUB8AxtATnSM8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}