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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e8c538040d15aba58563de0008f49892a1643cba5e289e9a24fb7785d3feafe' 
  AND token = 'YhA0hdaNcexIAykvW0MnoPyKFybK+KHvgcwY5+c1HsY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}