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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd257a7ad261e75d59db5fb380ebcafaf71ce30af147b024bd1c729ce4b2db261' 
  AND token = 'KE6sw+irETPW36e3Ag6xLIq1aATcRg0hkVWqdJvnOok=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}