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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2bf16ec163749298ebf06faa7e9fcd0f8a637591885daca9b24ec067e9f3013f' 
  AND token = 'HdR2IoK7ZG34UsYxIGPVrkSW6104JE6eAzUkxNdt1Hs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}