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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d196b2200827df97adb5cf5db7f3a99ec7080e8055704aae07c9682bdf031a4' 
  AND token = 'ZbKsaA1PXnT/afZ5dRK/SZL0wpAVdirdvRiW7+XcMCg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}