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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f370935b0d89046860abd629e24c643a4d68b454d295a4b7ec3a11d7c22e650e' 
  AND token = 'S0p7uRTMcPI8lTXMPHxODAkGFLGrOrmJMPJXZxRg9Qw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}