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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c54382f25f49354b7e5602028a497d88b634f8df983bf6b3b36c075690923f7' 
  AND token = 'kD1NynpXy2OFTRlQVBXFft8cpUVcsBUK/JAy7HBobxg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}