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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e1a9fbda701f1cb4b04bee0557b21f21c8511643d81d50a42a877da9b433430' 
  AND token = 'xVo+epkuNuosAfPkTxQs0KG857ULYt3+XVN+RQlwRCA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}