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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '821d8abcadd766af152e180dfca15c900ed49cbb08fdb7bffb90ff58ef7b49fd' 
  AND token = 'DbnzaZUBSacihrRzVNXiwLfi53uk2spvY+xi2z7BtQs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}