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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c80d376659f27644252d6e508bc5e131b3db6e3e2e9bdb665e23faa5553f61f1' 
  AND token = 'HPCOb852oZspXJWDWmkCjBqHcyIqMRxO5Byvpc8rYM0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}