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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c8df60a631fae6a1f1a75c4776b64fa50d02f77b2887e8ad8d60b865067ef5c' 
  AND token = 'EjWncv53VOzMjbZnULtz+F/FfxCyKZ0jtz+1R/WKUAk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}