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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6741b357d4ab64cc7600e9df34a708d0741e2e9a1c82f4399b1d8e53010d7a02' 
  AND token = 'heg04TZFjzZw81VPyuDUal50WPX6P56TELcYeXx679M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}