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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21418517046af03fe339b4b167e7d90f77b78b7cb12f2feb6ab2d2876f426179' 
  AND token = 'niPrhfJIFTOz6EZOkRsNMi93/llM9jIoNM+zqT55XRs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}