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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0a5343c54a5015035290457e5b44920f530c58a44e58a8f4bee6686c02c39a28' 
  AND token = 'QD47dFByTS9EsIyinw0RJ30DlS9/8j1M95bPVWkPEeo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}