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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7d321c965aa9eb61fddca275b4ecdd18c031caf2320fa3747fc53fe280fe5af0' 
  AND token = 'jGw1uCAmyc/fVn6fIvF/2LaD68HtE6rtUOkBlt7SxvU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}