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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7a5f25b307edfaa8ca6dc80ea04147f4ede6cd6d227c81e56497d2b7c5620052' 
  AND token = '+LqZy9SdOxBAIEEhN/Kqksm7l2kRVPnZ3TwpeCUyM3I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}