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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d012649ac2fb1344c90160e4ce65d1cd2025dd0ac5e362abd664f9328f125bf' 
  AND token = 'rO17LfTGO8HwyHGk5DZyeUdIDhM2JECRymaGWSkUZi8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}