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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ad9d009c7f6c69701fa0c823c45d303e8725514e57dd7341ae846009dfed6975' 
  AND token = 'TSV/WDeJzLa4Mce+jd51BeOlrnR5eCDFTFqNgKx1AVo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}