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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '280500e75e04c32469cb95e904d483dbfa1127632570560e5c8bc6db6a0122ca' 
  AND token = 'O63tIjf8UDldxLlonVufxutmtiQccomdr6I97O6Hak0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}