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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b946f58a0f27edbd1e3e6173f7f5002a5280b6307cca4a60ebe8a96845bb0222' 
  AND token = 'LgqUOl0EAi21+mbz8p3ciHo5oWo/YTw9XeiyoPPSoMM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}