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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d008309f2d663eccf7e52f170dc5c1e562ce396d3b32076e238017815f15dcc' 
  AND token = '+oh8D+xz6H0M4yQcn5TFA7JG2xLjyOQ+Xbt9QtLwS6c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}