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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e44497b2b79c3454dac6670be6e281b1bff0e34440944cce8d33f1563bac454' 
  AND token = 'vrV4NPTXUeeuZ6rTRdKi0zgLwyGUOLVYxybP5lnZ0d8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}