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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '04db16dc036b55cf5329d8096ba80ae7b7fd443c0c49e1a1c09c292374df6f80' 
  AND token = 'at8ZAy9ybOXGbA+VMWEcFWSjZXQ4VQvwqiDUFkFriUA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}