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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48eaf17dd7fda1b8c35cf84c7c77cd73f78043a45351a23b87db8b63993cd62d' 
  AND token = 'yv4Rk+fyF94zJh/cLFtRKjeAf0I7CLzclKWOOWgeT8Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}