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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '781c487769c76619480e89ea251140a15537f8b571b1e3813696de90cd051087' 
  AND token = 'zoOK2+MarMeY6RzF+CbcnP5qwYNH32+7kMWKfpPwpJs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}