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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b0ccf7621e28311380b6a874be812489082365d2bdcd22ab04f43a898d301643' 
  AND token = 'B7OdhQzpKawQUkebMjotgsb31V0o2JFa69WKCIDX0Us=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}