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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a78c22bb2bd1ced24b56dd46afb8cdd4243abb404475389f45322562df9e4e51' 
  AND token = 'CIKA6d2gipMSNBj6eC1BP1vZRbtE74PWy+hod23sL5g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}