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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e53a188955ee9849da0d063a3498a021868fae58f305627a6442b6a1a01aeb1' 
  AND token = 'SCcmI+/JmYHc5iG9UKDR93O5i4oj4tTkQ3yxYMnii6I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}