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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3eec850170b9f614590d2c82f7c63ccdc0b81bb1295e8c58974f59ff49c787c6' 
  AND token = 'JxT0jb4M9PI4b3EWN5t53MbU4DXeQ60BNqIgnjy4HVQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}