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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b781f904ce239f91ea45aea89bb5b6bf15db2bc62d005f617f179e88d8c28f85' 
  AND token = '46Is7PonA1pOm2UBJsirI6BOWyF20wVdtMym6sCVutU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}