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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '456e81dbe4acb7e7f94ae65fcbe0a681c2b11f5a753f4feb6eb22c4a1b38218c' 
  AND token = 'X0q11XhSl5w4/MscJkA+nFi6jVqxGkdn5uNMYtySidM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}