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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f0cc0810fa6474e1bc1a9b52ace249950bad3339e973c850f37d06283e3da841' 
  AND token = 'fK85qGgr5KINxdgX+GTh1QvN1U0FUyr294eWVPQYeAk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}