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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78377c33614b65a50a7e61b0e6fe92f5aecb4097ff8d2beeddca16518d2bcf35' 
  AND token = 'AzhQcwEBN57smjPJRWbHezxg0lZQOn1d4zFTRqt4hAA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}