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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22997521b46c799a401e8a38bb1ce5a71384e7b7919f2f8a176a4fd75b07a5bc' 
  AND token = 'WwSYEbzOCzcEIC/H2zVW6BzMFSKKnM8o2unU5OGSLeU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}