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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80a2d78fff19e0e53bd268091ffd7fcf61c9b7121f050e72682b4723743458cf' 
  AND token = 'Yt69Sw0tdBD5iZM8Jkf6LoRL3fMY507uF0zgWOJy5II=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}