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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45ad6ce5ca793b619982e0fc291b2e116a66de59695c7356459de4850e4f3d8a' 
  AND token = 'AN237sAOW48ju5bYrzO0BjU+3YurOdr8w5SyhfssWiY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}