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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b21d484cc4a7cc2d785a3acc598a74e21e92c2d774fe85f661a3fbcdcf0a6467' 
  AND token = 'HCBBdx4zHgZVC6lAp9iCcjkKCJrM0LUVeozua7lLkUg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}