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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1ca5822f8cae66fb88f3426c02083a135517307074b47e863c6d84bce4558ba4' 
  AND token = 'ED2Otv+k1Elqn5ZygTl0HZQoRt268G4tU+BD4tgBpiM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}