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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50cc288f6c13e8a51960290bf829c07d6d54e7de0713ccbdce48d4121e82c596' 
  AND token = 'P3j/7nnBE28R6D+ZpKNtd5wPNoBUUQlKZ0CTTRVJRpo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}